Bio-Retinol Youth Radiance Ultra helps with skin renewal and boosts collagen production. The cremeâs formulation helps restore skin giving it more clarity and reducing fine lines and wrinkles. It revives the skin to become healthy and gives you a youthful state. Bio Retinol works best when applied at night. Usually Bio-Retinol is a powerful active ingredient. Also it makes your skin photosensitive. So bio-retinol works best when you apply it at night.Bio-Retinol Youth Radiance Face Wash which not only cleans the dirt off your skin but is a lightweight formula that also targets various ageing symptoms like fine lines and crowâs feet.